15:45 – 16:15 Mathias Wenes: “Metabolic control of T cell differentiation”
16:15 – 16:45 Costas Lyssiotis: « Metabolic regulation of mitochondrial-ER contact »
Short talk #1: Charline Degavre (Belgium) – “Induction of immunogenic cell death by in situ photodynamic therapy to stimulate the response of peritoneal carcinomatosis to a dendritic cell-based vaccine”
Short talk #2: Giorgia Zadra (Italy) – “Obesogenic high-fat diet and oncogene Myc cooperate to remodel prostate cancer microenvironment through lactate accumulation”
Short talk #3: Raphaële Bombart (Belgium) – “Tryptophan depletion impairs CD8+ T-lymphocyte proliferation by preventing the activation-induced metabolic shift towards glycolysis”
Flash talks: Elena Richiardone (Belgium), Rebekah Crake (Belgium), Sandy Figiel (UK), Annarita Miluzio (Italy), Emanuele Vitale (Italy)
Fatima Mechta-Grigoriou: « Spatial mapping of stromal heterogeneity and immunosuppression in cancer”
09:45 – 10:15 Ping-Chih Ho: “Stressed out or adaptation in T cell differentiation and exhaustion”
10:15 – 10:45 Sarah-Maria Fendt: « Metabolic regulation driving metastasis formation”
Sara Sdelci: « Mitochondria-derived nuclear ATP surge protects against mechanical confinement-induced proliferation defects »
Short talk #1: Engy Vigneron (Belgium) – “Role of tumor-stroma metabolic crosstalk in the resistance to anti-EGFR therapy in head and neck cancers”
Short talk #2: Nguyen Nguyen (The Netherlands) – “Lactate controls cancer stemness and plasticity through epigenetic regulation”
Short talk #3: Rhianna Blyth (UK) – “Targeting the metabolic crosstalk between breast cancer cells and adipocytes using a novel 3D organotypic model”
Flash talks: Victoria Mohring (Belgium), Amelia Fasci (Italy), Miriam Lisci (Univ. Lausanne, Switzerland), Margherita Demicco (Belgium), Donatella Delle Cave (Italy)
14:15 – 14:45 Sirio Dupont: “Mitochondrial mechanotransduction coordinates the metabolic and transcriptional response to forces”
14:45 – 15:15 Akeila Bellahcène: “From glycation to epigenetic regulation: the multifaceted role of methylglyoxal in cancer”
Short talk #1: Adam Boufersaoui (UK) – “Nicotinamide nucleotide transhydrogenase (NNT) directly couples redox homeostasis to proline biosynthesis in hypoxic cancer cells”
Short talk #2: Thomas Daubon (France) – “Metabolic Adaptations of glioblastoma cells during tumor relapse”
Short talk #3: Alessandro Pasquarelli (Italy) – “Unveiling the influence of Citrate on Prostate Carcinoma Tropism to Bone by a Bone-on-a-Chip Platform”
Short talk #4: Michel Kahi (France) – “Eif5A hypusination shapes metabolic plasticity in prostate cancer”
16:45 – 17:15 Vignir Helgason: “Targeting critical metabolic traits of leukaemic stem cells”
17:15 – 17:45 Jean-Emmanuel Sarry: “Metabolic adaptation and mitochondrial signaling circuits in response to therapy in acute myeloid leukemia”
Short talk #1: Nick Van Gastel (Belgium) – “Acute myeloid leukemia cells require 18-carbon long fatty acids for protein S-acylation to maintain mitochondrial activity and metabolic plasticity”
Short talk #2: Elodie Viry (Luxembourg) “First-in-class MTHFD1 inhibitor eliminates malignant B cells in vitro and in vivo”
Short talk #3: Richard Burt (UK) – “Overcoming microenvironment-mediated resistance in Precursor B-cell Acute Lymphoblastic Leukaemia with the novel amino acid degrader Cyst(e)inase”
Short talk #4: Lavinia Ferrone (Italy) – “The mitochondrial chaperone TRAP1 in DLBCL lymphomagenesis”
09:45 – 10:15 Issam Ben-Sahra: “Nucleotide metabolism and control of cell growth”
10:15 – 10:45 Rushika Perera: “Identifying metabolic dependencies of primary and metastatic pancreatic cancers”
Andrea Morandi – “Exploiting metabolic vulnerabilities in breast cancer”
Short talk #1: Jurica Matkovic (Netherlands) – “Metabolic regulation of mitosis: Beyond ATP?”
Short talk #2: Abigail Strefeler (Switzerland) – “Nutrient-sensitized CRISPR/Cas9 screening reveals novel players in pyrimidine synthesis”
Short talk #3:Mohaned Benzarti (Luxembourg) – “PKM2 diverts glycolytic flux in dependence on mitochondrial one-carbon cycle”
14:30 – 15:00 Johannes Meiser: « Function(s) of formate in cancer »
15:00 – 15:30 Olivier Feron: “Tumor acidosis: driving cancer adaptation and revealing vulnerabilities”
Short talk #1: Lisa Butler (Australia) – “Cis-vaccenic acid is a critical oncogenic factor in prostate tumours”
Short talk #2: Morgane Paque (Belgium) – “mTORC2-dependent reprogramming of lipid metabolism is a metabolic vulnerability in lung cancer”
Short talk #3: Ning An (Belgium) – “tRNA wobble editing controls FSP1 expression and dictates ferroptosis sensitivity in lung cancer”
Short talk #4: Katarzyna Glowacka (Belgium) – “Acid-exposed, non-hypoxic cancer cells are highly dependent on fatty acid desaturase activity”